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Characterization of human monocytes activation by a water soluble preparation of Aphanizomenon flos-aquae
JANA vol. 2 (3): 59-65 Phytomedicine vol. 8 (6): 445-453
Author(s): N. Pugh, D.S. Pasco
ABSTRACT
Aphanizomenon flos-aquae (AFA) is fresh water microalgae that is consumed as a nutrient-dense food source and for its health enhancing properties. The current research characterizes the effect of a water soluble preparation from known agents that modulate the immune system. At 0.5 ng/ml the AFA extract robustly activated nuclear factor kappa B (NF-kappa B) directed luciferase expression in THP-1 human monocytic cells to levels at 50% of those achieved by maximal concentrations (10 ng/ml) of bacterial lipopoly saccharine (LPS). In addition, the AFA extract substantially increased mRNA levels of interleukin-1B (1L-1B) and tumor necrosis factor-(x (TNF-(x), and enhanced the DNA binding activity of NF-kappa B. The effects of AFA water soluble preparation were similar to the responses displayed by LPS, but clearly different from responses exhibited by tetradecanoyl phordol acetate (TPA) and interferon-gamma (INF-y). Pretreatment of THP-1 monocytes with factors known to induce hyproesponsiveness suppressed both AFA-dependent and LPS-dependent activation. These results suggest that the macrophage-activating properties of the AFA water soluble preparation are mediated through pathways that are similar to LPS-dependent activation.
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TESTIMONIES
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Our friends, Roger and Betty, visited their son in Florida and found his 11-year-old dog suffering with severe hip problems. Roger asked if they could provide Animal Algae for the dog. After two or three weeks, the dog was frisky and playful again. Roger wasn´t surprised since New Earth products are helping him, too! - Barb and Doral Clark Sauk City, Wisconsin
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